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Astralagus Benefits for a Healthier Liver, Gallbladder, and Gastrointestinal Tract

Posted by Deborah Graefer, L.Ac., MTOM on

Astralagus is the most studied herb in Traditional Chinese Medicine. For thousands of years, this has been the go-to plant for numerous ailments. Whether it is fatigue, diarrhea, lack of appetite, night sweats, sores and ulcers, stress, or the common cold, Chinese and alternative medicine practitioners swear by the potency of this adaptogen. It is also called Huang Qi, literally translated as ‘yellow leader’, because it is believed to be a superior tonic with a Qi restorative effect. Qi is a term used to refer to vital energy and is closely linked to overall strength, immunity, and longevity.

Astralagus is deemed to be so effective that it is now considered an official drug in the modern Pharmacopoeia of the People’s Republic of China. In the Western world, however, there is still insufficient clinical evidence on the medicinal benefits of Astralagus to influence the outcome of human diseases despite the sheer volume of pharmacological studies related to the plant. Nevertheless, it is slowly taking its ground as a supplement with its immunostimulant, antioxidative, cardioprotective, anti-inflammatory, antiviral, and stem cell stimulating properties.

Astralagus is a name of a plant genus with more than 2000 species. Among these, Astralagus membranaceus and Astralagus mongholicus are the most popularly used species for medicinal purposes. Other types of Astralagus contain notrotoxins and are not suitable for human consumption. The root of Astralagus is harvested from plants that are about four to five years old and is sold as dried slices, powder, shavings, whole root, shredded root, capsules, liquid extracts, tincture, and injectable forms.

Astralagus Components

There are more than 200 active constituents identified in the Astralagus species studied in the last few decades. The chemical components of various Astralagus types are highly uniform and mainly comprised of terpenoids, flavonoids, and polysaccharides called astragalans. Astralagus is also made up of various forms of saponins that show very interesting biological properties. The amounts of each component depend on the size, age, and growing conditions of the root.

a. Saponins

Many species of Astralagus have been proved to be rich in cycloartane-type saponins that help regulate cholesterol, protect the heart, fight depression, boost the immune system, and suppress tumor growth. Astralagus also has oleanane-type saponins.

b. Flavonoids

Astralagus, just like many other herbs, is a rich source of flavonoids. Flavonoids are plant metabolites that help in detoxifying the body while also keeping heart diseases and viruses at bay. Flavonoids also provide benefits through cell signaling.

c. Polysaccharides

By gas chromatography, researchers have identified that arabinose, fructose, glucose, and mannose monosaccharides are present in Astralagus. Polysaccharides have many health benefits too because of their antimicrobial, anti-inflammatory, and antiviral capabilities.

d. Others

Amino acids, proteins and minerals can be obtained from Astralagus genus plants. Examples of other components are folic acid, selenium, zinc, copper, calcium, potassium, and iron.

Astralagus Benefits

Astralagus (Huang Qi)…

- helps reduce inflammation.

- helps protect the liver

- supports healthy bile flow

- supports the immune system

- supports detoxification

- strengthens and protects the gastrointestinal tract

- increases proliferation of stem cells

Astralagus for Inflammation

Long before the discovery of inflammatory markers, chemokines, and cytokines, ancient medical practitioners already know that Astralagus helps heal sores and ulcerations. Now that scientific evidence is available, we understand that Huang Qi has that effect because of a variety of mechanisms.

1. Taking Astralagus helps in modulating signaling pathways of activator proteins (like NF-κB and AP-1) that play a role in the expression of many genes involved in inflammation, cancer development, and cell death.

2. Astralagus suppresses inflammation by decreasing the secretion of chemokines while increasing the human interleukin cytokine. This process inhibits the synthesis of pro-inflammatory cytokines and chemokines. IL-10 also upregulates immune responses and weakens cell-mediated immune reactions.

3. Lastly, Astralagus has an anti-inflammatory effect through the p38 mitogen-activated protein kinase (MAPK) known to regulate cytokine production.

All these actions combined make Astralagus a potential treatment for inflammatory diseases.

Astralagus for Liver Protection

Various studies have already proven the effectivity of Astralagus in the management of different liver conditions. It is believed that Astralagus treatment may cause significant improvement among patients with alcohol-induced fatty liver; so much so that it can help reverse liver damage. Regular intake of astralagus may also assist in keeping your cholesterol levels in check. Aside from reducing total and liver cholesterol and triglycerides, the herb is said to prevent fats from being absorbed from the intestines. It even facilitates accelerated evacuation of fats from the body.

Aside from those hepatic benefits, oral administration of Astralagus tincture on mice inhibits liver fibrosis and protects against liver damage by scavenging free radicals, decreasing levels of Transforming growth factor beta 1 or TGF-β1, a cytokine that is involved in cell growth, cell proliferation, and cell death. A similar experiment also showed how Huang Qi effectively slows down the progression of cholestatic liver fibrosis progression through the same mechanism. This liver disease may be caused by genetic or mechanical defects, toxins, or irregularities in the immune system that damage bile ducts and cause accumulation of bile.

Astralagus for Healthy Bile Flow and Gallbladder Function

Astralagus also helps the gallbladder and the liver since it affects bile acid biosynthesis. Huang Qi decreased accumulation of toxic bile in the liver, normalized serum bile acid levels, and increased the excretion of biliary and urinary bile acids. All these mechanisms make Astralagus an effective gallbladder protection by reversing the disordered homeostasis of bile acids.

Astralagus for Immune System Boost

What makes Astralagus a popular all-around remedy for TCM practitioners is its ability to support the immune system. 

Astralagus helps strengthen the body’s natural defenses by:

1. Activating immune cells – Astralagus administration significantly increases both humoral and cellular immune response through its ability to stimulate cell proliferation, induce the expression of antigens, enhance the maturation of T-cells, and promote the production of antibodies.

2. Decreasing overactive immune function in patients with autoimmune diseases – This was illustrated in patients with lupus, rheumatoid arthritis, and various allergies.

3. Acting as an adaptogenic herb, shielding the body from stress by supporting adrenal function and boosting detoxification.

4. Warding off some viruses and bacteria – Considering the wide variety of bacteria and viruses thriving around us, this claim still needs a lot of concrete evidence. At the moment, however, Astralagus has been used for vaccination against foot and mouth disease virus, Newcastle disease, virus, and Infectious bursal disease virus (IBDV).

Antioxidant and Anti-aging

Various research studies confirm that Astralagus helps in the body’s natural detoxification process. It serves as a scavenger for reactive oxygen species that causes free radical damage, a main component in disease development and aging.

Astralagus also protects our cells in various ways. Firstly, it helps shield the mitochondria, also known as the powerhouse of the cell responsible for metabolism and cell death. Aside from preventing premature cell death, this mechanism increases the activities of antioxidases. Astralagus also inhibits the process of aging in the cellular level by maintaining the health of telomeres. Telomeres are molecular caps found in each chromosome that are essential for proper cell function. The production of telomerase enzyme helps reverse the aging process.

Lastly, Astralagus intake helps in the detoxification as it up-regulates the expression of glutathione peroxidase. In our previous blog post, we discussed how we benefit from glutathione, our body’s natural antioxidant that unfortunately gets depleted over time.

Astralagus for the Gastrointestinal Tract

Astralagus helps strengthen and protect the gastrointestinal tract by improving the movement and muscle tonus in the intestine. It also helps lower excessive stomach acidity, increases the body’s metabolic rate, and promotes regular bowel elimination. In rat experiments, Astralagus is also proven to protect the colon from colitis (inflammation).

Regular intake of Huang Qi improves the composition of the gut microbiota. Animal experiments show that Astralagus supplementation increased beneficial Lactobacilli and Bacillus cereus numbers, while decreasing E. coli numbers.

Astralagus and Stem Cells

Stem cell treatment is one of the emerging viable alternative treatments for various health conditions like neurodegenerative, autoimmune, and inflammatory diseases. With the use of stem cell technology, patients with untreatable and chronic conditions like diabetes, rheumatoid arthritis, muscular dystrophy, and cancer are given hope with the possibility of getting better.

Astralagus, together with the other popular herbs in Chinese medicine play a role in the generation and protection of these stem cells. An example is a 2014 study on the potential of Chinese herbs to promote the proliferation, differentiation, and activation of neural stem cells and mesenchymal stem cells. Another similar study conducted in 2010 concluded that astragaloside IV found in Astralagus has a significant positive effect on the proliferation of mesenchymal stem cells and the increase of stem cell factors as exhibited in their animal experiments.

Astralagus Supplement

The Astralagus herb can be used when cooking soups and stews. Some people also boil the roots and drink the Astralagus tea. However, it may be challenging to do this every day to get your daily Huang Qi dose. That’s why Astralagus supplements in various forms are becoming more and more popular.

Astralagus supplements are considered safe for most adults. However, there is no standard or prescribed dosage. Some alternative medicine practitioners advise the following dosage:

Capsules: up to 500 mg three times a day

Tincture: 3-6 ml three times a day

Boiled Root: up to 15 grams of the Astralagus root in tea form

If you don’t have a trusted Astralagus supplement brand yet, you may try the following:

Pure Astragalus 2000mg Per Caps 200 Capsules (NON-GMO & Gluten Free)

Organic Astragalus 10:1 Extract Powder 4oz | HuangQi 10:1 Concentrate Granules

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